Formaldehyde (CH/sub 2/O) concentrations in the blood of humans and Fischer-344 rats exposed to CH/sub 2/O under controlled conditions
The effect of exposure to formaldehyde (CH/sub 2/O) on the CH/sub 2/O concentration of the blood was determined. Eight male F-344 rats were exposed to 14.4 +/- 2.4 ppm of CH/sub 2/O for 2 hours and the blood was collected immediately after exposure. Formaldehyde concentrations in the blood were determined by gas chromatography/mass spectrometry. The blood of eight rats unexposed to CH/sub 2/O was collected and analyzed in the same manner. Measured CH/sub 2/O concentrations (..mu..g/g of blood) were: controls, 2.24 +/- 0.07; exposed, 2.25 +/- 0.07 (mean +/- S.E.). Formaldehyde concentrations in human blood were determined by analyzing samples of venous blood collected before and after exposure of six human volunteers (4 M, 2 F) to 1.9 +/- 0.1 ppm of CH/sub 2/O for 40 min. Average CH/sub 2/O concentrations (..mu..g/g of blood) were: before exposure, 2.61 +/- 0.14; after exposure, 2.77 +/- 0.28. In neither experiment was there a statistically significant effect of exposure on the average CH/sub 2/O concentration of the blood. However, human subjects differed significantly with respect to their blood CH/sub 2/O concentrations, and significant differences (either an increase or a decrease) were found between the CH/sub 2/O concentrations of the blood taken before and after exposure from some of the subjects, suggesting that blood CH/sub 2/O concentrations may vary with time.
- Research Organization:
- Chemical Industry Institute of Toxicology, Research Triangle Park, NC
- OSTI ID:
- 5551428
- Report Number(s):
- CONF-8505143-
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Vol. 46:1; Conference: American Industrial Hygiene conference, Las Vegas, NV, USA, 19 May 1985
- Country of Publication:
- United States
- Language:
- English
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FORMALDEHYDE
BLOOD CHEMISTRY
BLOOD
CONTROLLED ATMOSPHERES
GAS CHROMATOGRAPHY
INHALATION
MAN
MASS SPECTROSCOPY
RATS
TIME DEPENDENCE
TISSUE DISTRIBUTION
ALDEHYDES
ANIMALS
ATMOSPHERES
BIOLOGICAL MATERIALS
BODY FLUIDS
CHROMATOGRAPHY
DISTRIBUTION
INTAKE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PRIMATES
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)