Growth of SJL/J-derived transplantable reticulum cell sarcoma as related to its ability to induce T-cell proliferation in the host- III. Studies on thymectomized and congenitally athymic SJL mice. [Mice]

Journal Article · Sun Nov 15 00:00:00 EST 1981 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(81)90054-X· OSTI ID:5549371

Katz, I R ^[1]; Chapman-Alexander, J; Jacobson, E B; Lerman, S P; Thorbecke, G J

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1. New York Univ. School of Medicine, New York

When SJL mice are irradiated and reconstituted with syngeneic bone marrow (XBM) they support growth of transplantable reticulum cell sarcoma to approximately 60% of that in normal mice. The ability to support RCS growth gradually improves with time after irradiation and reaches 90% of normal by 8-12 weeks. However, if the mice are thymectomized 4 weeks prior to treatment (Tx-XBM) they initially show 50% which increases to only 65% of growth in normal mice after 12 weeks. The ability of lymphoid cells from these mice to proliferate in vitro in response to irradiated RCS cells is normal 4 weeks after treatment in XBM, but remains <10% of normal in Tx-XBM mice. Nude mice of SJL background also show greatly diminished RCS growth. It is concluded that T cells promote RCS growth in vivo possibly via their tendency to proliferate upon exposure to RCS.

• OSTI ID: 5549371
• Journal Information: Cell. Immunol.; (United States), Vol. 65:1
• Country of Publication: United States
• Language: English

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BIOLOGICAL RADIATION EFFECTS
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CELL CULTURES
CELL PROLIFERATION
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CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
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LEUKOCYTES
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NUCLEI
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560121* - Radiation Effects on Cells- External Source- (-1987)