Sequential hemibody and local irradiation with combination chemotherapy for small cell lung carcinoma: a preliminary analysis
Sequential hemibody irradiation (SHB) was integrated with combination chemotherapy and local irradiation (LRT) in the induction and consolidation phases of a therapeutic protocol for small cell lung carcinoma (SCLC). Forty-one previously untreated patients were entered into this program. Among 38 evaluable patients (20 with limited disease (LD) and 18 with extensive disease (ED)), the overall response rate was 63% (90% in LD and 33% in ED patients). The estimated overall survival is 8.1 months. The major toxicity has been myelosuppression - especially thrombocytopenia. The frequency of previously described acute radiation syndromes and radiation pneumonitis associated with hemibody irradiation have been substantially decreased at the current dosage with premedication and shielding techniques.
- Research Organization:
- Wake Forest Univ., Winston-Salem, NC
- OSTI ID:
- 5548340
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:3
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
DIARRHEA
RADIOINDUCTION
IMMUNOSUPPRESSION
PNEUMONITIS
RADIOTHERAPY
SIDE EFFECTS
CARCINOMAS
CHEMOTHERAPY
DOXORUBICIN
ENDOXAN
LUNGS
ONCOVIN
PARTIAL BODY IRRADIATION
PATIENTS
ALKALOIDS
ALKYLATING AGENTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BODY
DISEASES
DRUGS
EXTERNAL IRRADIATION
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
RADIOLOGY
RESPIRATORY SYSTEM
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)