Prolonged RNA changes in the Hermissenda eye induced by classical conditioning
- National Institutes of Health, Bethesda, MD (USA)
The incorporation of {sup 32}P into mRNA and the total amount of mRNA were increased 3- to 4-fold in eyes isolated from Hermissenda crassicornis trained to associate light with rotation on a turntable compared with animals trained with equal numbers of light and rotation events presented randomly and with naive animals. Incorporation of {sup 32}P into poly(A){sup {minus}} RNA was reduced by as much as 60%. The RNA changes were strongly correlated with the degree of learning and could not be accounted for by changes in ({sup 32}P)ATP content. The RNA changes were maximal at 24 hr and were still detectable after 4 days, indicating that associative conditioning produces a period of increased DNA transcription that could be an intermediate step in memory consolidation. The RNA changes may in part account for recently observed conditioning-specific changes in the synthesis rates of specific proteins.
- OSTI ID:
- 5547011
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:20; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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MESSENGER-RNA
BIOSYNTHESIS
MOLLUSCS
CONDITIONED REFLEXES
BEHAVIOR
EYES
LEARNING
PHOSPHORUS 32
TRANSCRIPTION
VISIBLE RADIATION
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
FACE
HEAD
INVERTEBRATES
ISOTOPES
LIGHT NUCLEI
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
RADIATIONS
RADIOISOTOPES
REFLEXES
RNA
SENSE ORGANS
SYNTHESIS
550201* - Biochemistry- Tracer Techniques