Dose-response analysis for boron neutron capture therapy of the B16 murine melanoma using p-boronophenylalanine

Conference · Mon Jan 01 00:00:00 EST 1990

OSTI ID:5546307

Coderre, J A; Micca, P L; Slatkin, D N; Makar, M S

Boron Neutron Capture Therapy (BNCT) of a well-pigmented B16 melanoma implanted subcutaneously in the mouse thigh has been carried out at the Brookhaven Medical Research Reactor (BMRR) using the synthetic amino acid p-boronophenylalanine (BPA) as the boron delivery agent. The response of the B16 melanoma to BNCT was compared with the response to 250 kVp x-rays using both tumor growth delay and in vivo/in vitro assay that measures clonogenic survival. These experiments allow a comparison of tumor growth delay, log cell kill and damage to normal tissues produced by BNCT or photon irradiation.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: USDOE; NIOSH; USDOE, Washington, DC (USA); National Inst. for Occupational Safety and Health, Rockville, MD (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5546307
• Report Number(s): BNL-46150; CONF-901226-5; ON: DE91013806; CNN: CA42446 (JAC)
• Resource Relation: Conference: 4. international symposium on neutron capture therapy, Sydney (Australia), 3-7 Dec 1990
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EXPERIMENTAL NEOPLASMS
DOSE-RESPONSE RELATIONSHIPS
IMPLANTS
MELANOMAS
NEUTRON CAPTURE THERAPY
MICE
BIOLOGICAL RADIATION EFFECTS
BORON 10
CELL CULTURES
CELL KILLING
DOSE EQUIVALENTS
FAST NEUTRONS
MRR REACTOR
NITROGEN 14
PERFORMANCE TESTING
PHENYLALANINE
RBE
SURVIVAL CURVES
X RADIATION
AMINO ACIDS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BORON ISOTOPES
CARBOXYLIC ACIDS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
FERMIONS
HADRONS
IONIZING RADIATIONS
IRRADIATION REACTORS
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NEUTRONS
NITROGEN ISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
STABLE ISOTOPES
TANK TYPE REACTORS
TESTING
THERAPY
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
550603* - Medicine- External Radiation in Therapy- (1980-)