Biologically important compounds in synfuels processes
Crude products, by-products and wastes from synfuel processes contain a broad spectrum of chemical compounds - many of which are active in biological systems. Discerning which compound classes are most important is necessary in order to establish effective control over release or exposure. Polycyclic aromatic hydrocarbons (PAH), multialkylated PAH, primary aromatic amines and N-heterocyclic PAH are significant contributors to the overall mutagenic activities of a large number of materials examined. Ames test data show that the basic, primary aromatic amine fraction is the most active. PAHs, multialkylated PAHs and N-heterocyclic PAHs are all components of the neutral fraction. In nearly all cases, the neutral fractions contribute the largest portion of the mutagenic activity, while the basic primary aromatic amine fractions have the highest specific activity. Neutral fractions are usually the largest (wt %) whereas the total basic fractions are small by comparison; thus, the overall greater contribution of the neutral fraction to the mutagenic activity of most samples. Biologically active constituents are isolated in preparative scale amounts from complex mixtures utilizing combinations of liquid-liquid extraction and various liquid chromatographic column-eluant combinations. Fractions are characterized using a combination of spectroscopic techniques and gas chromatography/mass spectrometry.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5536406
- Report Number(s):
- CONF-800303-13
- Resource Relation:
- Conference: 179. national meeting of the American Chemical Society, Houston, TX, USA, 23 Mar 1980
- Country of Publication:
- United States
- Language:
- English
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37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
01 COAL, LIGNITE, AND PEAT
04 OIL SHALES AND TAR SANDS
POLYCYCLIC AROMATIC HYDROCARBONS
SEPARATION PROCESSES
SYNTHETIC FUELS
MUTAGEN SCREENING
AMINES
AROMATICS
BY-PRODUCTS
EXTRACTION
FLOWSHEETS
GAS CHROMATOGRAPHY
LIQUID COLUMN CHROMATOGRAPHY
MUTAGENS
SPECTROSCOPY
TOXICITY
WASTES
CHROMATOGRAPHY
DIAGRAMS
FUELS
HYDROCARBONS
ORGANIC COMPOUNDS
SCREENING
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
400301 - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)
016000 - Coal
Lignite
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040700 - Oil Shales & Tar Sands- Health & Safety