Effect of venous injection site on accuracy of fast computed tomography (CT) estimation of myocardial perfusion

Conference · Mon Feb 26 00:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5532113

Bell, M R; Rumberger, J A; Lerman, L O; Behrenbeck, T; Sheedy, P F; Ritman, E L ^[1]

---

1. Mayo Clinic, Rochester, MN (United States)

Measurement of myocardial perfusion with fast CT, using venous injections of contrast, underestimates high flow rates. Accounting for intramyocardial blood volume improves the accuracy of such measurements but the additional influence of different contrast injection sites is unknown. To examine this, eight closed chest anesthetized dogs (18-24 kg) underwent fast CT studies of regional myocardial perfusion which were compared to microspheres (M). Dilute iohexol (0.5 mL/kg) was injected over 2.5 seconds, via, in turn, the pulmonary artery (PA), proximal inferior vena cava (IVC) and femoral vein (FV) during CT scans performed at rest and after vasodilation with adenosine (M flow range: 52-399 mL/100 g/minute). Correlations made with M were not significantly different for PA vs IVC (n = 24), PA vs FV (n = 22) and IVC vs FV (n = 44). To determine the relative influence of injection site on accuracy of measurements above normal flow rates (> 150mL/100g/minute), CT flow (mL/100g/minute; mean {+-}SD) was compared to M. Thus, at normal flow, some CT overestimation of myocardial perfusion occurred with PA injections but FV or IVC injections provided for accurate measurements. At higher flow rates only PA and IVC injections enabled accurate CT measurements of perfusion. This may be related to differing transit kinetics of the input bolus of contrast.

• OSTI ID: 5532113
• Report Number(s): CONF-9004153-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 4:3; Conference: 74. annual meeting of the Federation of American Societies for Experimental Biology, Washington, DC (United States), 1-5 Apr 1990; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
COMPUTERIZED TOMOGRAPHY
MYOCARDIUM
DYNAMIC FUNCTION STUDIES
ACCURACY
BLOOD FLOW
DOGS
INTRAVENOUS INJECTION
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
INJECTION
INTAKE
MAMMALS
MUSCLES
ORGANS
TOMOGRAPHY
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)