Cytogenetic rogue cells: what is their frequency, origin, and evolutionary significance
Among 102,170 cultured lymphocytes obtained from 9818 individuals from Hiroshima, Japan, aged 9 to 37 years and scored for chromosomal abnormalities, 24 cells that exhibited an extreme degree of damage were encountered. The damage consists of multiple dicentric and even tricentric chromosomes, as well as numerous fragments, many with the appearance of double minutes. The occurrence of these cells was not correlated with parental exposure to the atomic bomb, age, sex, year, or season. They were nonrandomly distributed by individual. Such cells were originally described in South American Indians and have also been recorded in inhabitants of the United States and the United Kingdom; this appears to be a world-wide phenomenon. Their cause remains unknown, and it is not known whether they occur in other somatic and germ-line cells. Should the latter be the case and should the least damaged of these cells occasionally successfully complete mitosis and meiosis, the possible role of such cells in oncogenesis and evolution must be considered.
- Research Organization:
- Radiation Effects Research Foundation, Hiroshima, Japan
- OSTI ID:
- 5528567
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
A-BOMB SURVIVORS
CELL CULTURES
HIROSHIMA
JAPAN
ANIMAL CELLS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
HUMAN POPULATIONS
LEUKOCYTES
MATERIALS
MUTATIONS
POPULATIONS
RADIATION EFFECTS
SOMATIC CELLS
560151* - Radiation Effects on Animals- Man
560121 - Radiation Effects on Cells- External Source- (-1987)