Personal exposure and health effect relationship for NO2 with urinary hydroxyproline to creatinine ratio as indicator

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1986.9935764· OSTI ID:5526567

Yanagisawa, Y; Nishimura, H; Matsuki, H; Osaka, F; Kasuga, H

Establishment of an exposure-effect relationship was attempted between personal nitrogen dioxide (NO/sub 2/) exposure and urinary hydroxyproline to creatinine ratio of approximately 800 adult women, who were mothers of primary schoolchildren living in two communities around Tokyo. Daily average of the personal NO/sub 2/ exposure (ENO/sub 2/) was measured during wintertime by a newly developed personal monitor exposed for 24 hours. The hydroxyproline to creatinine ratio (HOP:C) in the urine sample collected early in the morning of the day for ENO/sub 2/ measurement was used as a biochemical indicator of the health effect of NO/sub 2/ exposure. The HOP:C was found to have significant correlation with ENO/sub 2/ and number of cigarettes smoked actively and passively. ENO/sub 2/, however, had no correlation with the intensity of the smoking levels; they might affect HOP:C independently. Stepwise multiple regression analysis revealed that HOP:C could be predicted by ENO/sub 2/ and smoking habits at a high confidence level. The regression analysis of the active smokers group indicated that a few cigarettes was enough to increase the HOP:C, while in the case of passive smoking, HOP:C increased proportionally to the number of cigarettes.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 5526567
• Journal Information: Arch. Environ. Health; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
CREATININE
QUANTITY RATIO
HYDROXYPROLINE
NITROGEN DIOXIDE
AIR POLLUTION MONITORING
HEALTH HAZARDS
BIOLOGICAL INDICATORS
ENVIRONMENTAL EXPOSURE
JAPAN
REGRESSION ANALYSIS
SEASONAL VARIATIONS
TOBACCO SMOKES
AEROSOLS
AMINES
AMINO ACIDS
ASIA
AZOLES
CARBOXYLIC ACIDS
CHALCOGENIDES
COLLOIDS
DISPERSIONS
HAZARDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
IMIDAZOLES
IMINES
MATHEMATICS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PYRROLES
PYRROLIDINES
RESIDUES
SMOKES
SOLS
STATISTICS
VARIATIONS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)