Effect of ethanol on droplet size, efficiency of delivery, and clearance characteristics of technetium-99m DTPA aerosol
With recent technical advances in aerosol technology, the study of regional ventilation using (/sup 99m/Tc)DTPA aerosol has become increasingly popular. Using a cascade impactor, the authors have assessed droplet size distribution from a newly designed nebulizer. Delivery efficiency of (/sup 99m/Tc)DTPA aerosol to normal subjects was improved 70% with a 10% concentration of ethanol in the nebulizer. Using filter paper fixed to the delivery end of the aerosol device, and varying ethanol concentrations from 0-10%, an 87% increase of deposited radioactivity is measured. The addition of ethanol did not alter clearance characteristics of (/sup 99m/Tc)DTPA from the lung nor did it affect droplet size distribution.
- Research Organization:
- Univ. of Minnesota School of Medicine, Minneapolis
- OSTI ID:
- 5524637
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:6
- Country of Publication:
- United States
- Language:
- English
Similar Records
{sup 99m}Tc DTPA aerosol clearances in the assessment of radiation injury top the lung
Lung clearance of inhaled /sup 99m/Tc-DTPA in the dog
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOACTIVE AEROSOLS
CHEMICAL PREPARATION
RADIOPHARMACEUTICALS
CHEMICAL PROPERTIES
TECHNETIUM 99
LUNG CLEARANCE
CASCADE IMPACTORS
DROPLETS
DTPA
ETHANOL
ISOMERIC NUCLEI
SIZE
AEROSOLS
ALCOHOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARTICLES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SOLS
SYNTHESIS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics