Piotron. II. Methods and initial results of dynamic pion therapy in phase II studies
Negative pi-meson (pion) therapy employing dynamic scanning with a focused spot of convergent beams has been in use since 1981 at SIN. Three-dimensional conformation of the treatment volume to the target volume can thus be achieved. Following previously reported Phase I and Ib clinical trials, a Phase II trial was initiated with the goal of treating primary deep-seated tumors in a dose optimization schedule which included stepwise increase of total pion dose and of target volume. Patients with multicentric superficial bladder tumors who were cystectomy candidates were initially selected. Since then, more invasive cases have been treated. Treatment reactions ranged from a faint erythema and increase of bladder frequency to dry desquamation, mild nausea, moderate dysuria, and moderate proctitis or diarrhea with mucus. These reactions were closely related to treatment volume and site. One severe late cystitis has occurred in a patient treated with 2 courses of pions (4475 rad). Mild to moderate late proctitis has been seen in 4 patients. Ten of 13 bladder cancer patients had local control of disease while all 3 pancreas or biliary tract cancer patients had microscopic residual disease locally at time of death from metastasis. A total of 11 of 17 patients are thus clinically or pathologically free of local tumor to time of last observation.
- Research Organization:
- Swiss Institute for Nuclear Research, Villigen
- OSTI ID:
- 5519844
- Report Number(s):
- CONF-8310342-; TRN: 85-015625
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:2; Conference: 25. annual meeting of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 3 Oct 1983
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BILIARY TRACT
BIOLOGICAL RADIATION EFFECTS
BLADDER
DIARRHEA
RADIOINDUCTION
ERYTHEMA
NAUSEA
PANCREAS
PROCTITIS
RADIOTHERAPY
SIDE EFFECTS
SKIN
PATIENTS
PIGMI FACILITIES
PIONS MINUS
ACCELERATOR FACILITIES
ACCELERATORS
BIOLOGICAL EFFECTS
BODY
BOSONS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELEMENTARY PARTICLES
ENDOCRINE GLANDS
GLANDS
HADRONS
MEDICINE
MESON FACTORIES
MESONS
NUCLEAR MEDICINE
ORGANS
PIONS
PSEUDOSCALAR MESONS
RADIATION EFFECTS
RADIOLOGY
SYMPTOMS
THERAPY
URINARY TRACT
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)