Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Molecular and Cellular Biology; (USA)

DOI:https://doi.org/10.1128/MCB.9.3.1342· OSTI ID:5518583

Lubon, H K; Hennighausen, L ^[1]; Ghazal, P; Reynolds-Kohler, C; Lockshin, C; Nelson, J ^[2]

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1. Lab. of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (US)
2. Scripps Clinic and Research Foundation, La Jolla, CA (USA)

In this paper the authors demonstrate that modular sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effort on the level of transcription in a variety of cells and that this region has the capacity to interact with specific nuclear protein. Depending on the cell type, these modulator sequences increased or decreased transcriptional activation from the IE1 gene promoter-enhancer. The cell lines identified in this report should be useful to study the molecular mechanism of cell-specific transcriptional repression and activation exerted by the major immediate-early promoter upstream region.

• OSTI ID: 5518583
• Journal Information: Molecular and Cellular Biology; (USA), Vol. 9:3; ISSN 0270-7306
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA SEQUENCING
GENES
SPECIFICITY
TRANSCRIPTION
GENE REGULATION
GENE AMPLIFICATION
GENE REPRESSORS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550200* - Biochemistry