Trichinella spiralis: differences between early and late rapid expulsion evident from inhibition studies using cortisone and irradiation
Cortisone administered once at 100 mg/kg during the first 3 weeks of infection inhibited rapid expulsion. In rats immunized with an abbreviated infection (T/M regime) inhibition averaged approximately 50%, whereas in rats given a complete infection (C.I.) 14% inhibition occurred. Sensitivity to 400 rad whole-body irradiation was greatest 7 days before a challenge infection in all immune rats. Three days after beginning the T/M infection rats were highly susceptible to cortisone but only weakly so to irradiation. Rats immunized by C.I. were equally, but only weakly, susceptible to either cortisone or irradiation 3 days after infection. Acute administration of cortisone 1 or 4 hr prior to challenge did not inhibit rapid expulsion but 60% inhibition occurred when cortisone was given 24 hr prior to challenge. Inhibition of rapid expulsion by irradiation 7 days prior to challenge was not reversed by immune serum and irradiation did not affect antibody titer in treated rats. It was suggested that irradiation 7 days before challenge compromised the intestinal, and not the immunological, component of rapid expulsion. Differences in sensitivity of early and late rapid expulsion to irradiation and cortisone therapy provide further evidence of functional differences between these rejection processes.
- Research Organization:
- Cornell Univ., Ithaca
- OSTI ID:
- 5517370
- Journal Information:
- Exp. Parasitol.; (United States), Vol. 64:3
- Country of Publication:
- United States
- Language:
- English
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CORTISONE
RADIOSENSITIVITY EFFECTS
TRICHINELLA
INFECTIVITY
RADIOSENSITIVITY
ANTIBODIES
ENZYME IMMUNOASSAY
INHIBITION
RATS
TRICHINOSIS
WHOLE-BODY IRRADIATION
ADRENAL HORMONES
ANIMALS
ASCHELMINTHES
CORTICOSTEROIDS
DISEASES
EXTERNAL IRRADIATION
GLUCOCORTICOIDS
HELMINTHS
HYDROXY COMPOUNDS
IMMUNOASSAY
INFECTIOUS DISEASES
IRRADIATION
KETONES
MAMMALS
NEMATODES
ORGANIC COMPOUNDS
PARASITIC DISEASES
PREGNANES
RODENTS
STEROIDS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals