Effect of DMSO and DMBA hamster pouch carcinogenesis

Conference · Thu Jan 01 00:00:00 EST 1987 · Proc. Soc. Exp. Biol. Med.; (United States)

OSTI ID:5516545

Rivera-Hidalgo, F; Miller, E G; Binnie, W H

The penetration of mucosal surfaces by chemical carcinogens is required for tumor induction. The effectiveness of dimethyl sulfoxide (DMSO) as a carrier for carcinogen is controversial. The purpose of this study was to determine what effect DMSO would have on the 9,10-dimethyl- 1,2-benzanthracene (DMBA)-induced carcinogenesis in the hamster cheek pouch. Thirty Syrian golden hamsters were divided into two groups: the control group received a topical application of 0.5% DMBA in mineral oil three times per week for 16 weeks, while the experimental group received a topical application of DMSO previous to each DMBA application. At autopsy, both groups had developed tumors, the tumor ratio of control to experimental was 3.5:1.9 and the average size of tumors was 2.2 to 1.9 mm sq. The results suggest that DMSO interfered with the usual DMBA induction mechanism.

• Research Organization: Baylor College of Dentistry, Dallas, TX
• OSTI ID: 5516545
• Report Number(s): CONF-8610349-
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 184:4; Conference: Annual meeting of the Southwest Section of the Society for Experimental Biology and Medicine, Oklahoma City, OK, USA, 17 Oct 1986
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
CARCINOGENESIS
DMSO
BIOLOGICAL EFFECTS
FACE
EXPERIMENTAL NEOPLASMS
HAMSTERS
ANIMALS
AROMATICS
BODY
BODY AREAS
CONDENSED AROMATICS
HEAD
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
RODENTS
SULFOXIDES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology