Practical SPECT technique for quantitation of drug delivery to human tumors and organ absorbed radiation dose

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Seminars in Nuclear Medicine; (USA)

DOI:https://doi.org/10.1016/S0001-2998(89)80034-0· OSTI ID:5515637

Iosilevsky, G; Israel, O; Frenkel, A; Even-Sapir, E; Ben-Haim, S; Front, A; Kolodny, G M; Front, D ^[1]

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1. Rambam Medical Center, Haifa (Israel)

A practical quantitative single photon emission computed tomographic (SPECT) technique based on an empirical threshold analysis permits accurate measurements in humans of drug delivery and absorbed radiation dose. The limits of the method have been explored using a wide range of phantom volumes, concentrations, and target-to-nontarget ratios. A threshold of 43% was found to give the best results using volumes of 30 to 3,800 cc. An excellent correlation (r = .99 with a standard error of estimate (SEE) of 41 cc) was found between SPECT measured volumes and actual phantom volumes. A similarly high correlation (r = .98, SEE = 260 counts/voxel) was found in 77 measurements of concentrations between 0.01 and 3.6 microCi/cc. There was a direct relationship between the target-to-nontarget ratio of phantoms and the accuracy of volume measurements. The technique has been validated by an excellent in vivo/in vitro correlation of uptake in human tumors. The tumor cumulative concentration and tumor-to-blood ratio were used for assessment of drug delivery. In vivo quantitative measurements of the pharmacokinetics of technetium-99m (99mTc) glucoheptonate, cobalt-57 (57Co) bleomycin and platinum-195m (195mPt) cisplatin in human tumors in vivo indicates that, in contrast with tumor models in animals, there is a marked variability in drug delivery even in tumors with the same histology. Future development of labeled drugs should make it possible to use quantitative SPECT for predicting tumor response to therapy and for tailoring chemotherapy for the individual patient under treatment. SPECT quantitation of organ concentration was used for Medical Internal Radiation Dose committee (MIRD) calculations of organ absorbed radiation dose from 99mTc-labeled RBCs. 48 references.

• OSTI ID: 5515637
• Journal Information: Seminars in Nuclear Medicine; (USA), Vol. 19:1; ISSN 0001-2998
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
61 RADIATION PROTECTION AND DOSIMETRY
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SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
ACCURACY
BLOOD
COBALT 57
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HEART
ISOMERIC NUCLEI
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TECHNETIUM 99
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CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOCUMENT TYPES
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ELECTRON CAPTURE RADIOISOTOPES
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EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
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ISOTOPES
MAMMALS
MATERIALS
MOCKUP
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLATINUM ISOTOPES
PRIMATES
RADIOISOTOPES
STABLE ISOTOPES
STRUCTURAL MODELS
TECHNETIUM ISOTOPES
TESTING
TOMOGRAPHY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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