Male vs. female mediated teratogenesis
Different types of reproductive dysfunction with exposure of males and females during different stages of the reproductive process were correlated. It is a well-established principle that teratogenic exposure of the pregnant female, and thus of the embryo, during the organogenesis period of development can lead to birth defects in the offspring. The outcome of this exposure paradigm, as well as the outcomes associated with exposure during other stages of the reproductive process that have received less experimental attention are discussed. Insult to the germ cells of the male during spermatogenesis and to the female during oogenesis can also lead to reproductive dysfunction. The type of adverse outcome, however, is quite different from that occurring with embryonic exposure during the organogenesis period. An overview of this area will be given with the intent of focusing on those types of reproductive dysfunction that are most relevant to environmental exposure of men and women.
- Research Organization:
- Cincinnati Univ., OH (USA)
- OSTI ID:
- 5514739
- Report Number(s):
- N-8326407
- Country of Publication:
- United States
- Language:
- English
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IONIZING RADIATIONS
TERATOGENESIS
CHROMOSOMES
DEFECTS
FERTILITY
GENETIC RADIATION EFFECTS
GENETICS
HORMONES
MITOSIS
OOGENESIS
REPRODUCTIVE DISORDERS
SPERMATOGENESIS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CELL DIVISION
GAMETOGENESIS
GENETIC EFFECTS
RADIATION EFFECTS
RADIATIONS
560151* - Radiation Effects on Animals- Man