Osteonecrosis in patients irradiated for head and neck carcinoma
One hundred patients irradiated for cancers of the oral cavity, oropharynx, and nasopharynx were evaluated for the occurrence of osteonecrosis and associated predisposing factors. Selection was based on availability of complete dental records, a minimum of six months follow-up, and treatment fields, which included maxilla and/or mandible. Bone doses were calculated by using radiotherapy treatment records, port films, and isodose distributions. Osteonecrosis developed in 19 of 78 dentulous patients and in 3 of 22 edentulous patients. The time of development of osteonecrosis varied; in 15 cases osteonecrosis occurred more than one year after treatment. The most important risk factor for the development of osteonecrosis was the radiation dose to bone, particularly in the less vascular mandible. Osteonecrosis 7500 rads to the bone. None of the patients who received less than 6500 rads developed osteonecrosis. The risk was significantly greater when teeth were removed after therapy compared with those individuals with extractions before radiation or no extractions at all.
- OSTI ID:
- 5513898
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 47:8
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
BIOLOGICAL RADIATION EFFECTS
OSTEORADIONECROSIS
RADIOINDUCTION
COMPARATIVE EVALUATIONS
HEAD
NECK
PARTIAL BODY IRRADIATION
PATIENTS
RADIATION DOSES
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
SKELETON
TEETH
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
DOSES
EXTERNAL IRRADIATION
INJURIES
IRRADIATION
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
SKELETAL DISEASES
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man