Histogenesis and progression of ultraviolet light-induced tumors in hairless mice
Tumor histogenesis and progression were studied in UV-irradiated albino (Skh:hairless-1) and lightly pigmented (Skh:hairless-2) hairless mice. A strongly carcinogenic dose of UV light was used, producing 100% tumor incidence by 35 weeks. The light source emitted mainly UV radiation in the range of 280-320 nm and the less energetic UV radiation up to 400 nm. The resulting epidermal changes and neoplasms resembled those seen in the actinically damaged skin of humans. Microscopic lesions included benign hyperplasia, actinic keratoses, and squamous cell carcinoma in situ and with microinvasion. Clinical tumors were epithelial papillomas, fibropapillomas, keratoacanthomas, cystic keratomas, benign pigmented macules, cutaneous hornlike growths, exophytic and endophytic squamous cell carcinomas of several cytologic types, and fibrosarcomas. Even with this high dose of UV radiation, not all of the small tumors progressed to cancer. Many regressed, including some keratoacanthomas, whereas others remained small and benign for the lifetime of the mouse.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 5511433
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 67:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EPIDERMIS
MORPHOLOGICAL CHANGES
PATHOLOGICAL CHANGES
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
MICE
NEOPLASMS
ANIMAL TISSUES
ANIMALS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
EPITHELIUM
MAMMALS
ORGANS
PATHOGENESIS
RADIATIONS
RODENTS
SKIN
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals