Relationship between dose of injected /sup 239/Pu and bone sarcoma mortality in young adult beagles

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575797· OSTI ID:5511119

Peterson, A V; Prentice, R L; Marek, P

The effect of /sup 239/Pu on bone sarcoma mortality in young adult beagles is examined using data from a follow-up study conducted at the Radiobiology Laboratory at the University of Utah. A (proportional-hazards) model, which specifies that bone sarcoma mortality depends on both dose of injected plutonium and time since injection as the product of a dose factor and a time factor, is used both for describing the data and for performing inference about the relationship between dose of plutonium and bone sarcoma mortality. Relative bone sarcoma mortality rates are found to be approximately linear as a function of dose. There is evidence that relative bone sarcoma mortality decreases with time since injection.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 5511119
• Journal Information: Radiat. Res.; (United States), Vol. 90:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAGLES
RADIOSENSITIVITY
OSTEOSARCOMAS
RADIOINDUCTION
PLUTONIUM 239
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
MORTALITY
RADIATION DOSES
RADIATION HAZARDS
TIME DEPENDENCE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
DISEASES
DOGS
DOSES
EVEN-ODD NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOISOTOPES
SARCOMAS
SKELETAL DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells