Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats
Abstract
Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent (v/v) d4-MOF. Serum and urinary F- and serum urea nitrogen and creatinine were measured. Urine volume and urinary F- excretion were only slightly greater among MOF than among d4-MOF exposed animals. Pretreatment with PB, however, greatly enhanced F- production in MOF-exposed animals leading to marked renal impairment but only slightly enhanced F- production in d4-MOF animals leading to mild renal impairment. Thus, only in PB-pretreated animals could a biologically significant difference in nephrotoxicity be demonstrated for MOF and d4-MOF.
- Authors:
- Publication Date:
- Research Org.:
- Stanford University School of Medicine, Veterans Administration Medical Center, Palo Alto
- OSTI Identifier:
- 5510629
- Resource Type:
- Journal Article
- Journal Name:
- Anesthesiology; (United States)
- Additional Journal Information:
- Journal Volume: 56:3
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANESTHESIA; BIOLOGICAL EFFECTS; KIDNEYS; BIOLOGICAL FUNCTIONS; ORGANIC FLUORINE COMPOUNDS; TOXICITY; ANESTHETICS; CREATININE; DEUTERIUM COMPOUNDS; FLUORIDES; RATS; UREA; URINE; AMIDES; ANIMALS; AZOLES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CARBONIC ACID DERIVATIVES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; FLUORINE COMPOUNDS; FUNCTIONS; HALIDES; HALOGEN COMPOUNDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; IMIDAZOLES; IMINES; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RODENTS; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
Citation Formats
Baden, J M, Rice, S A, and Mazze, R I. Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats. United States: N. p., 1982.
Web. doi:10.1097/00000542-198203000-00009.
Baden, J M, Rice, S A, & Mazze, R I. Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats. United States. https://doi.org/10.1097/00000542-198203000-00009
Baden, J M, Rice, S A, and Mazze, R I. 1982.
"Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats". United States. https://doi.org/10.1097/00000542-198203000-00009.
@article{osti_5510629,
title = {Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats},
author = {Baden, J M and Rice, S A and Mazze, R I},
abstractNote = {Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent (v/v) d4-MOF. Serum and urinary F- and serum urea nitrogen and creatinine were measured. Urine volume and urinary F- excretion were only slightly greater among MOF than among d4-MOF exposed animals. Pretreatment with PB, however, greatly enhanced F- production in MOF-exposed animals leading to marked renal impairment but only slightly enhanced F- production in d4-MOF animals leading to mild renal impairment. Thus, only in PB-pretreated animals could a biologically significant difference in nephrotoxicity be demonstrated for MOF and d4-MOF.},
doi = {10.1097/00000542-198203000-00009},
url = {https://www.osti.gov/biblio/5510629},
journal = {Anesthesiology; (United States)},
number = ,
volume = 56:3,
place = {United States},
year = {Mon Mar 01 00:00:00 EST 1982},
month = {Mon Mar 01 00:00:00 EST 1982}
}