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Title: Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury

Abstract

OBJECTIVES: To assess the effects of chronic xerostomia on parameters of gastroesophageal reflux and esophagitis. DESIGN: Observational study of a cohort of male patients with xerostomia and age-matched control subjects. SETTING: Tertiary-care Veterans Affairs Medical Center. SUBJECTS: Sixteen male patients with chronic xerostomia secondary to radiation for head and neck cancers or medications. Nineteen age-matched male control subjects with comparable alcohol and smoking histories. MEASUREMENTS AND MAIN RESULTS: Esophageal motility was similar in patients with xerostomia and controls. Clearance of acid from the esophagus and 24-hour intraesophageal pH were markedly abnormal in patients with xerostomia. Symptoms and signs of esophagitis were significantly more frequent in subjects with xerostomia. CONCLUSIONS: Chronic xerostomia may predispose to esophageal injury, at least in part, by decreasing the clearance of acid from the esophagus and altering 24-hour intraesophageal pH. Esophageal injury is a previously unreported complication of long-term salivary deficiency.

Authors:
; ; ; ; ;  [1]
  1. Gastrointestinal Section, Veterans Affairs Medical Center, Bronx, New York (USA)
Publication Date:
OSTI Identifier:
5506294
Resource Type:
Journal Article
Journal Name:
American Journal of Medicine; (United States)
Additional Journal Information:
Journal Volume: 90:6; Journal ID: ISSN 0002-9343
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ESOPHAGUS; BIOLOGICAL RADIATION EFFECTS; HEAD; NEOPLASMS; NECK; RADIOTHERAPY; SIDE EFFECTS; PATIENTS; RADIATION INJURIES; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DIGESTIVE SYSTEM; DISEASES; INJURIES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Korsten, M A, Rosman, A S, Fishbein, S, Shlein, R D, Goldberg, H E, and Biener, A. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. United States: N. p., 1991. Web. doi:10.1016/S0002-9343(05)80058-0.
Korsten, M A, Rosman, A S, Fishbein, S, Shlein, R D, Goldberg, H E, & Biener, A. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. United States. https://doi.org/10.1016/S0002-9343(05)80058-0
Korsten, M A, Rosman, A S, Fishbein, S, Shlein, R D, Goldberg, H E, and Biener, A. 1991. "Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury". United States. https://doi.org/10.1016/S0002-9343(05)80058-0.
@article{osti_5506294,
title = {Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury},
author = {Korsten, M A and Rosman, A S and Fishbein, S and Shlein, R D and Goldberg, H E and Biener, A},
abstractNote = {OBJECTIVES: To assess the effects of chronic xerostomia on parameters of gastroesophageal reflux and esophagitis. DESIGN: Observational study of a cohort of male patients with xerostomia and age-matched control subjects. SETTING: Tertiary-care Veterans Affairs Medical Center. SUBJECTS: Sixteen male patients with chronic xerostomia secondary to radiation for head and neck cancers or medications. Nineteen age-matched male control subjects with comparable alcohol and smoking histories. MEASUREMENTS AND MAIN RESULTS: Esophageal motility was similar in patients with xerostomia and controls. Clearance of acid from the esophagus and 24-hour intraesophageal pH were markedly abnormal in patients with xerostomia. Symptoms and signs of esophagitis were significantly more frequent in subjects with xerostomia. CONCLUSIONS: Chronic xerostomia may predispose to esophageal injury, at least in part, by decreasing the clearance of acid from the esophagus and altering 24-hour intraesophageal pH. Esophageal injury is a previously unreported complication of long-term salivary deficiency.},
doi = {10.1016/S0002-9343(05)80058-0},
url = {https://www.osti.gov/biblio/5506294}, journal = {American Journal of Medicine; (United States)},
issn = {0002-9343},
number = ,
volume = 90:6,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1991},
month = {Sat Jun 01 00:00:00 EDT 1991}
}