Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study
Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not yet well established. Therefore, in this study, the effects of this drug on ultimate infarct size were examined quantitatively. Another member of the same class of drugs, droxicainide (ALS1249), DL-N-(2-hydroxyethyl)-pipecolinyl-2,6-dimethylanilide hydrochloride, is a new antiarrhythmic agent that has shown a good therapeutic index in the initial experimental studies. Accordingly, the effects of this drug on ultimate infarct size were examined and compared with those of lidocaine. Coronary artery occlusion was performed on 29 dogs. One minute later, technetium-99m labeled microspheres were injected into the left atrium for assessment of the hypoperfused zone (the zone at risk of infarction). Fifteen minutes after occlusion, the dogs were randomized into three groups: 9 dogs served as a control group, 10 were given lidocaine and 10 were given the same dosage of droxicainide. Six hours after occlusion, the dogs were sacrificed and the hearts cut into 3 mm thick slices and incubated in triphenyltetrazolium chloride to delineate the area of myocardial damage. Autoradiography of the same slices provided images of the areas of myocardial hypoperfusion. Thereafter, in each dog, the percent of hypoperfused area that evolved to necrosis was calculated. In control dogs, it was 85.6 +/- 2.0%; in lidocaine-treated dogs, 68.1 +/- 4.1% (p less than 0.01), a reduction of 20%; and in droxicainide-treated dogs, 50.1 +/- 5.3%, a reduction of 41% (p less than 0.001 versus control and p less than 0.005 versus lidocaine).
- Research Organization:
- Deborah Cardiovascular Research Institute, Browns Mills, New Jersey
- OSTI ID:
- 5504454
- Journal Information:
- J. Am. Coll. Cardiol.; (United States), Vol. 1:6
- Country of Publication:
- United States
- Language:
- English
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ANESTHETICS
BIOLOGICAL EFFECTS
MYOCARDIAL INFARCTION
THERAPY
MYOCARDIUM
NECROSIS
TECHNETIUM
DIAGNOSTIC USES
DOGS
HEART
ISCHEMIA
ANIMALS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
ELEMENTS
MAMMALS
METALS
MUSCLES
ORGANS
PATHOLOGICAL CHANGES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics