Vascular adrenergic receptor responses in skeletal muscle in myotonic dystrophy

Journal Article · Sun Feb 01 00:00:00 EST 1981 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410090209· OSTI ID:5504395

Mechler, F; Mastaglia, F L

The pharmacological responses of vascular adrenergic receptors to intravenously administered epinephrine, phentolamine, and propranolol were assessed by measuring muscle blood flow (MBF) changes in the tibialis anterior muscle using the xenon 133 clearance technique and were compared in 8 normal subjects and 11 patients with myotonic dystrophy. In cases with advanced involvement of the muscle, the resting MBF was reduced and was not significantly altered by epinephrine before or after alpha- or beta-receptor blockade. In patients in whom the tibialis anterior muscle was normal or only minimally affected clinically, a paradoxical reduction in the epinephrine-induced increase in MBF was found after alpha blockade by phentolamine, and the epinephrine-induced MBF increase was not completely blocked by propranolol as in the normal subjects. These findings point to functional alteration in the properties of vascular adrenergic receptors in muscle in myotonic dystrophy. While this may be another manifestation of a widespread cell membrane defect in the disease, the possibility that the changes are secondary to the myotonic state cannot be excluded.

• OSTI ID: 5504395
• Journal Information: Ann. Neurol.; (United States), Vol. 9:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
MUSCLES
BLOOD FLOW
VASCULAR DISEASES
DIAGNOSIS
XENON 133
DIAGNOSTIC USES
ADRENALINE
CELL MEMBRANES
CLEARANCE
PATHOLOGY
PATIENTS
RECEPTORS
ADRENAL HORMONES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEMBRANES
NEUROREGULATORS
NUCLEI
RADIOISOTOPES
STEROID HORMONES
SYMPATHOMIMETICS
USES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques