Neonatal body water turnover: a putative index of perinatal morbidity
The water metabolism of 46 newborn babies was determined during a 10 day period by means of an isotope dilution technique, and correlations were sought with the clinical assessment of the babies by multiple obstetric and pediatric clinical criteria. The babies, 48 to 72 hours of age, were given a single oral dose (2 ml/kg) of deuterated water (D/sub 2/O), a nonradioactive tracer, and the urinary excretion rate was followed by means of infrared spectrophotometry. After a period of equilibration of the D/sub 2/O with body water (20 hours), the rate of D2O clearance was found to be a single exponential decay process, thus allowing the fraction of total body water lost each hour (the rate constant) to be calculated for each baby. The median values of the rate constants X 10(4)(h-1) for 14 growth-retarded babies ws 104 (98% confidence limits, 97.8 to 122) compared with 76.3 (67.0 to 80.2) for 16 normal mature babies and 82.1 (73.4 to 90.6) for 16 normal premature babies. These data indicate that, compared with normal mature or normal premature babies, growth-retarded infants have a significantly (P less than 0.05) faster turnover of water during the first 10 days of postnatal life. Since there was little overlap in results between the normally grown and the retarded infants, the measurement of water turnover may provide a useful index of perinatal morbidity.
- OSTI ID:
- 5504230
- Journal Information:
- Am. J. Obstet. Gynecol.; (United States), Vol. 139:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
HEAVY WATER
METABOLISM
RETENTION FUNCTIONS
MEASURING METHODS
COMPARATIVE EVALUATIONS
DEUTERIUM
EXCITATION
GROWTH
GYNECOLOGY
INHIBITION
ISOTOPE DILUTION
NEONATES
STATISTICS
TIME DEPENDENCE
ENERGY-LEVEL TRANSITIONS
FUNCTIONS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATHEMATICS
MEDICINE
NUCLEI
ODD-ODD NUCLEI
OXYGEN COMPOUNDS
STABLE ISOTOPES
TRACER TECHNIQUES
WATER
550501* - Metabolism- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics