Serium levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions
Polychlorinated biphenyls and some organochlorine insecticides (DDT isomers and their metabolites, indane (..gamma..-BHC), dieldrin, heptachlor epoxide) were assessed in the serum of 17 women with recent missed abortions, 7 women who experienced one or several missed abortions in their past, and 7 women with normal, second trimester pregnancy. Fifty-three percent of the cases of recent missed abortion had PCB serum levels higher than the mean plus two standard deviations of the control group. The mean PCB serum level in women with recent missed abortion and relatively high PCB serum levels was significantly different from that of the control group (103.04 versus 20.69 ppb,P<0.001). The mean PCB serum level of the former missed abortions group was also significantly different from that of the control group (82.00 versus 20.69 ppb, P<0.001). The quantity of the higher chlorinated biphenyl homologues (penta- and hexachlorobiphenyls) was increased in the high PCB level, missed abortion group and in the former missed abortion group, while the lower chlorinated biphenyl homologues were decreased in these groups in comparsion with the control group. The fact that the former missed abortion group showed increased PCB serum levels similar to those found in the high PCB level, recent missed abortion group confirms the existence of an association between relatively high PCB serum levels and the occurance of missed abortion. (JMT)
- Research Organization:
- Hadassah Medical School, Jerusalem, Israel
- OSTI ID:
- 5504164
- Journal Information:
- Environ. Res.; (United States), Vol. 30:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL EFFECTS
FETUSES
ABORTION
BLOOD SERUM
ORGANIC CHLORINE COMPOUNDS
PATIENTS
PREGNANCY
REPRODUCTIVE DISORDERS
AROMATICS
HALOGENATED AROMATIC HYDROCARBONS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)