Female reproductive potential after treatment for Hodgkin's disease
The probability of maintaining ovarian function, becoming pregnant, and delivering a normal child is important to young women anticipating successful therapy for Hodgkin's disease. In this study, reproductive function was retrospectively examined in 103 women 40 years old or younger who had undergone treatment for Hodgkin's disease with total-lymphoid irradiation (TLI) alone, combination chemotherapy, or combined TLI and chemotherapy. Infertility was directly related to gonadal exposure to therapy and to age at treatment. Twenty women became pregnant after receiving total-nodal irradiation or combination chemotherapy or both. No fetal wastage occurred, and no birth defects were seen in the 24 infants born to these women. Even after intensive treatment programs, women successfully treated for Hodgkin's disease have become pregnant and delivered phenotypically normal children.
- OSTI ID:
- 5503929
- Journal Information:
- New Engl. J. Med.; (United States), Vol. 304:23
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HODGKINS DISEASE
RADIOTHERAPY
REPRODUCTION
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
LYMPH NODES
NEONATES
PATIENTS
PHENOTYPE
PREGNANCY
RADIOSENSITIVITY
REPRODUCTIVE DISORDERS
SIDE EFFECTS
WOMEN
ANIMALS
BIOLOGICAL EFFECTS
DISEASES
FEMALES
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PRIMATES
RADIATION EFFECTS
RADIOLOGY
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man
551000 - Physiological Systems