Androgen uptake in the female reproductive system of a nonhuman primate

Journal Article · Wed Jul 15 00:00:00 EDT 1981 · Am. J. Obstet. Gynecol.; (United States)

OSTI ID:5503271

Weaker, F J; Sheridan, P J

The nuclear uptake and retention of /sup 3/H-dehydrotestosterone (/sup 3/H-DHT) were studied in the reproductive organs of the female rhesus monkey by autoradiography. Ovariectomized and adrenalectomized adult female monkeys were injected with 1 microgram of /sup 3/H-DHT (107 Ci/mmole) and were exsanguinated 1 hour later. The uterus, cervix, vagina, and fimbriae of the fallopian tubes were removed and processed for autoradiography. Localization of the androgen was observed in the nuclei of fibroblasts, but not in the nuclei of smooth muscle and tissues of the blood vessels, of all four organs. The uptake of androgen by the epithelium varied for each organ. The simple columnar epithelium of the fallopian tube demonstrated nuclear labeling, but the epithelium of the uterus did not. The cells of the germinative layer of the stratified squamous epithelium of both the cervix and vagina exhibited nuclear concentration of label; however, the simple columnar epithelium of the cervix contiguous with the uterus was free of label. The results suggest that androgens may have a physiologic role in the female reproductive organs, and that the therapeutic effect of drugs such as danazol may be mediated via an androgen receptor.

• OSTI ID: 5503271
• Journal Information: Am. J. Obstet. Gynecol.; (United States), Vol. 140:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
UPTAKE
FEMALE GENITALS
AUTORADIOGRAPHY
FEMALES
FIBROBLASTS
MACACUS
PHYSIOLOGY
QUANTITATIVE CHEMICAL ANALYSIS
RETENTION
TRITIUM COMPOUNDS
ANDROSTANES
ANIMAL CELLS
ANIMALS
BODY
CHEMICAL ANALYSIS
CONNECTIVE TISSUE CELLS
HORMONES
LABELLED COMPOUNDS
MAMMALS
MONKEYS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SOMATIC CELLS
STEROID HORMONES
STEROIDS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques