The effect of naloxone and cyproheptadine on pulmonary platelet trapping, hypotension, and platelet aggregability in traumatized dogs

Journal Article · Sun May 01 00:00:00 EDT 1983 · J. Trauma; (United States)

DOI:https://doi.org/10.1097/00005373-198305000-00008· OSTI ID:5502933

Almqvist, P; Kuenzig, M; Schwartz, S I

Adult respiratory distress syndrome (ARDS) is a serious complication of trauma and sepsis. We have earlier shown naloxone, an opiate antagonist, and cyproheptadine, an antiserotonin drug, to be effective in reducing pulmonary platelet trapping (PPT), which is thought to play an important role in the evolution of ARDS in endotoxin-shocked dogs. Endorphins are implicated as pathophysiologic factors in shock, and serotonin is a possible mediator of their action. The present study shows naloxone and cyproheptadine to be equally effective in protecting against PPT in dogs subjected to trauma, and when naloxone is given before the trauma it also obviates the hypotension associated with trauma. In addition, the naloxone- and cyproheptadine-treated animals did not show the increased platelet aggregability usually seen in traumatized dogs.

• Research Organization: Department of Surgery, University of Rochester School of Medicine and Dentistry Medical Center, Strong Memorial Hospital, New York
• OSTI ID: 5502933
• Journal Information: J. Trauma; (United States), Vol. 23:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
RESPIRATORY SYSTEM DISEASES
THERAPY
BLOOD PLATELETS
DOGS
DRUGS
ENDORPHINS
ENDOTOXINS
INJURIES
RESPIRATION
ANIMALS
ANTIGENS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DISEASES
MAMMALS
MATERIALS
NEUROREGULATORS
TOXIC MATERIALS
TOXINS
VERTEBRATES
550900* - Pathology