Vascular effects of cigarette smoke in isolated pig lungs
To determine the local effects of cigarette smoke on the pulmonary vasculature, we measured pulmonary artery pressure--flow curves in isolated, blood-perfused pig lungs before and after 4 exposures to cigarette smoke. During each exposure, smoke was administered into the trachea for 3 to 4 min at a rate of 20 to 25 puffs/min and a puff volume of 35 to 50 ml with a smoking machine. During hypoxia (inspired PO2, 50 mmHg), when baseline vasomotor tone was high, cigarette smoke caused an acute transient vasodilation. During control (inspired PO2, 200 mmHg), when baseline tone was low, no significant effect was observed. In addition to this acute effect, cigarette smoke caused a depression of the pulmonary pressor response to hypoxia, which developed gradually during the course of the experiment. Indomethacin, at perfusate concentrations of 20 and 100 micrograms/ml, did not significantly alter the acute vasodilating effect of smoking, suggesting that prostaglandins synthesized by cyclooxygenase were not the mediators of this response. Indomethacin did, however, prevent the gradual depression of the pulmonary vasoconstrictor response to hypoxia.
- Research Organization:
- Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD
- OSTI ID:
- 5499430
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Vol. 124:5
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BLOOD VESSELS
SENSITIVITY
LUNGS
BLOOD FLOW
TOBACCO SMOKES
BIOLOGICAL EFFECTS
ANOXIA
BIOLOGICAL PATHWAYS
PERFUSED ORGANS
PROSTAGLANDINS
SWINE
VASODILATION
AEROSOLS
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
COLLOIDS
DISPERSIONS
DOMESTIC ANIMALS
MAMMALS
ORGANS
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems