Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA cross linking agents

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860080111· OSTI ID:5499021

Lee, T C; Lee, K C; Tzeng, Y J; Huang, R Y; Jan, K Y

To see if sodium arsenite enhances the clastogenicity and the mutagenicity of DNA crosslinking agents, Chinese hamster ovary (CHO) cells and human skin fibroblasts were exposed to cis-diamminedichloroplatinum (II) (cis-Pt(II)) or 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet light (UVA) and then to sodium arsenite. The results indicate that the clastogenicity of cis-Pt(II) and 8-MOP pllus UVA are enhanced by the post-treatment with sodium arsenite. Chromatid breaks and exchanges are predominantly increased in doubly treated cells. Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells

• Research Organization: Institute of Zoology, Taipei, Taiwan
• OSTI ID: 5499021
• Journal Information: Environ. Mutagen.; (United States), Vol. 8:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARSENIC COMPOUNDS
SYNERGISM
CHO CELLS
CHROMOSOMAL ABERRATIONS
FIBROBLASTS
NEAR ULTRAVIOLET RADIATION
PLATINUM COMPOUNDS
CROSS-LINKING
DNA
MAN
MUTAGENESIS
PSORALEN
SKIN
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BODY
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
COUMARINS
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
POLYMERIZATION
PRIMATES
RADIATIONS
SOMATIC CELLS
TRANSITION ELEMENT COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
560121 - Radiation Effects on Cells- External Source- (-1987)