The UCLA population studies of chronic obstructive respiratory disease. IV. Respiratory effect of long-term exposure to photochemical oxidants, nitrogen dioxide, and sulfates on current and never smokers

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5498897

Detels, R; Sayre, J W; Coulson, A H; Rokaw, S N; Massey, Jr, F J; Tashkin, D P; Wu, M M

Questionnaires, spirometry, and the single-breath nitrogen test were administered to 3,192 participants 25 to 39 yr of age in area exposed to low concentrations of all pollutants (Lancaster, California) and to 2,369 similar participants living in an area exposed to high concentrations of photochemical oxidants, nitrogen dioxide, and sulfates (Glendora, California). The prevalence of symptoms and results in the majority of the tests were worse in the polluted area between current and never smokers and men and women. Those tests associated primarily with small airways (Vmax50, Vmax75, delta N 2(750-1250) showed little or no difference between areas. The difference in the prevalence of participants with a poor FEV1 and/or poor FEV1 and/or poor FVC and in the mean Vmax and closing volume was greater between areas than between smoking categories. These results suggest that long-term exposure to high concentrations of photochemical oxidants, NO2, and sulfates at place of residence may result in measurable impairment in both current smokers and never smokers. Firmer documentation of this effect will require following these populations for changes in lung function that correlate with pollutant exposures.

• Research Organization: School of Public Health, University of California, Los Angeles
• OSTI ID: 5498897
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 124:6
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
DYNAMIC FUNCTION STUDIES
LOS ANGELES
LUNGS
MAN
NITROGEN DIOXIDE
PHOTOCHEMICAL OXIDANTS
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ORGANS
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OXYGEN COMPOUNDS
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560306* - Chemicals Metabolism & Toxicology- Man- (-1987)