Renin responses to hemorrhage to conscious rats
The authors investigated the role of beta adrenergic inhibition on the renin response to graded hemorrhage (hem) in conscious rats. Chronic femoral arterial (for measurement of mean arterial pressure - MAP) and venous (for drug infusion) catheters were implanted at least 5 days before experimentation. Hem was administered in < 2 min. 10 rats (CTL) were exposed to a total of 21 episodes of hemorrhage. 13 rats (B-block) were given 1 mg/kg propranolol hydrochloride iv 20 min prior to hem (24 episodes total). Plasma renin activity (PRA) was measured by radioimmunoassay. Pre-hem PRA levels were measured in the first 1 ml of hem blood. Hem resulted in hem volume-dependent decreases in blood pressure and increases in PRA. B-block did not significantly alter the mean renin response to hemorrhage.
- Research Organization:
- Medical College of Wisconsin, Milwaukee
- OSTI ID:
- 5497036
- Report Number(s):
- CONF-8604222-; TRN: 86-026636
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEMORRHAGE
BIOLOGICAL EFFECTS
RENIN
ENZYME ACTIVITY
BLOOD PLASMA
BLOOD PRESSURE
RADIOIMMUNOASSAY
RATS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
ENZYMES
HYDROLASES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
NONSPECIFIC PEPTIDASES
PATHOLOGICAL CHANGES
PEPTIDE HYDROLASES
RADIOASSAY
RADIOIMMUNOLOGY
RODENTS
SYMPTOMS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques