Differential inhibition of organic cations by the renal tubule of the chicken: relationship to Tm

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5496661

Springate, J; Hasan, M; Rennick, B; Acara, M

The ability of organic cations to differentially inhibit the renal excretion of two prototypical organic cations, tetraethylammonium (TEA) and N/sup 1/-methylnicotinamide (NMN), was investigated using the Sperber technique in chickens. /sup 3/H-TEA and /sup 14/C-NMN were infused simultaneously into the renal portal circulation and their transport efficiencies (TE) determined to be 106 +/- 11% and 81 +/- 13% respectively. Quinine, unlabelled NMN or TEA, added in increasing amounts, produced differential inhibition of TEA, NMN, or cimetidine (infused in separate experiments). Data using other competing organic cations (guinidine, ranitidine, triethylcholine) indicated that TEA was never more susceptible to inhibition than NMN. These results suggest that the magnitude of T/sub m/ is directly related to susceptibility to inhibition and indirectly to inhibitory potency.

• Research Organization: SUNY, Buffalo, NY
• OSTI ID: 5496661
• Report Number(s): CONF-8604222-; TRN: 86-026674
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMMONIUM COMPOUNDS
EXCRETION
INHIBITION
NICOTINAMIDE
CARBON 14 COMPOUNDS
CATIONS
CHICKENS
KIDNEYS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUBULES
AMIDES
ANIMALS
AZINES
BIRDS
BODY
CHARGED PARTICLES
CLEARANCE
FOWL
HETEROCYCLIC COMPOUNDS
IONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
VERTEBRATES
VITAMIN B GROUP
VITAMINS
550501* - Metabolism- Tracer Techniques