Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum arabic in roden germ cells

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860080305· OSTI ID:5492730

Sheu, C W; Cain, K T; Rushbrook, C J; Jorgenson, T A; Generoso, W M

Ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic are generally recognized as safe (GRAS) substances that are used primarily as additives in foods. These substances were incorporated into rodent diets and fed to male rats and mice for 10 and 8 wk, respectively. The treated male mice and rats were then tested for dominant lethal effects. The mice were also tested for induced heritable translocation. Results of the rat studies indicated a statistically significant dominant lethal effect of each of the compounds tested; however, the biological significance of this response is not known. Results of the mouse dominant lethal and heritable translocation studies, on the other hand, indicated no adverse effects of the compounds tested.

• Research Organization: Food and Drug Administration, Washington, DC
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5492730
• Journal Information: Environ. Mutagen.; (United States), Vol. 8:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDITIVES
GENETIC EFFECTS
MUTAGEN SCREENING
CRESOLS
GUM ACACIA
DIET
DOMINANT MUTATIONS
FOOD
LETHAL MUTATIONS
MICE
RATS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
HYDROXY COMPOUNDS
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
PHENOLS
POLYSACCHARIDES
RODENTS
SACCHARIDES
SCREENING
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)