Search for DNA conformational features for functional sites. Investigation of the TATA box
- Institute of Cytology and Genetics, Novosibirsk (Russian Federation)
A method for searching for DNA conformational features significant for functional sites is developed. The method uses helical angles averaged for known X-ray structures. Nucleotide sequences are assigned mean angles in a given region. Choice of the significant angles is based on their capabilities to discriminate functional sites from random sequences. The yeast, invertebrate, and vertebrate TATA boxes are analyzed using this method. Regions neighboring the TATA boxes are found to have smaller helical twist and roll angles. The results agree with the experimental data on Dickerson-Drew dodecamers. There is a significant decrease in the length of a small roll angle region with increasing complexity of taxon organization. 28 refs., 3 figs., 3 tabs.
- OSTI ID:
- 549265
- Report Number(s):
- CONF-970132-; TRN: 97:005592-0035
- Resource Relation:
- Conference: Pacific symposium on biocomputing `97, Kapalua, HI (United States), 6-9 Jan 1997; Other Information: PBD: 1996; Related Information: Is Part Of Pacific symposium on biocomputing `97: Proceedings; Altman, R.B. [ed.] [Stanford Univ., CA (United States). Section on Medical Informatics]; Dunker, A.K. [ed.] [Washington State Univ., Pullman, WA (United States). Dept. of Biochemistry and Biophysics]; Hunter, L. [ed.] [National Insts. of Health, Bethesda, MD (United States). National Library of Medicine]; Klein, T.E. [ed.] [California Univ., San Francisco, CA (United States). Dept. of Pharmaceutical Chemistry]; PB: 508 p.
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
DNA
CONFORMATIONAL CHANGES
STRUCTURE-ACTIVITY RELATIONSHIPS
HELICAL CONFIGURATION
ALGORITHMS
BIOLOGICAL EVOLUTION
MATHEMATICAL MODELS
EXPERIMENTAL DATA
NUMERICAL ANALYSIS
GENES
TRANSCRIPTION
GENE REGULATION
DNA HELICASES
NUCLEOTIDES
AMINO ACIDS