Algorithm to assemble pathways from processes

Conference · Tue Dec 31 00:00:00 EST 1996

OSTI ID:549261

Mittenthal, J E ^[1]

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1. Univ. of Illinois, Urbana, IL (United States)

To understand or to modify a biological pathway, the first step is to determine the patterns of coupling among its processes that are compatible with its input-output relation. Algorithms for this purpose have been devised for metabolic pathways, in which the reactions typically leave the enzymes unmodified. As shown here, one of these algorithms can also assemble molecular networks in which reactions modify proteins, if the proteins are included among the inputs to the reactions. Thus one procedure suffices to assemble pathways for metabolism, cytoplasmic signal transduction, and gene regulation. 9 refs., 3 figs.

• OSTI ID: 549261
• Report Number(s): CONF-970132-; TRN: 97:005592-0031
• Resource Relation: Conference: Pacific symposium on biocomputing `97, Kapalua, HI (United States), 6-9 Jan 1997; Other Information: PBD: 1996; Related Information: Is Part Of Pacific symposium on biocomputing `97: Proceedings; Altman, R.B. [ed.] [Stanford Univ., CA (United States). Section on Medical Informatics]; Dunker, A.K. [ed.] [Washington State Univ., Pullman, WA (United States). Dept. of Biochemistry and Biophysics]; Hunter, L. [ed.] [National Insts. of Health, Bethesda, MD (United States). National Library of Medicine]; Klein, T.E. [ed.] [California Univ., San Francisco, CA (United States). Dept. of Pharmaceutical Chemistry]; PB: 508 p.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
ALGORITHMS
PERFORMANCE
ENZYMES
GENE REGULATION
METABOLISM
BIOLOGICAL EVOLUTION
BIOSYNTHESIS
PROTEINS
BIOLOGICAL PATHWAYS
COUPLING
MATHEMATICAL MODELS
DYNAMIC FUNCTION STUDIES
CHEMICAL REACTIONS
CHEMICAL REACTION KINETICS
GLYCOGEN
MOLECULES