Combinatorial tools for the analysis of transcriptional regulation

Conference · Tue Dec 31 00:00:00 EST 1996

OSTI ID:549241

Bergeron, A; Gaul, E; Bergeron, D ^[1]

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1. Universite du Quebec a Montreal (Canada)

In this paper, we discuss virtual experiments for the study of major regulatory processes such as translation, signalization or transcription pathways. An essential part of these processes is the formation of protein clusters held together by a small number of binding domains that can be shared by many different proteins. Analysis of these clusters is complicated by the vast number of different arrangements of proteins that can trigger a specific reaction. We propose combinatorial tools that can help predict the effects on the rate of transcription of either changes in transcriptional factors concentration, or due to the introduction of chimeras combining domains not usually present on a protein. 15 refs., 5 figs., 3 tabs.

• OSTI ID: 549241
• Report Number(s): CONF-970132-; TRN: 97:005592-0011
• Resource Relation: Conference: Pacific symposium on biocomputing `97, Kapalua, HI (United States), 6-9 Jan 1997; Other Information: PBD: 1996; Related Information: Is Part Of Pacific symposium on biocomputing `97: Proceedings; Altman, R.B. [ed.] [Stanford Univ., CA (United States). Section on Medical Informatics]; Dunker, A.K. [ed.] [Washington State Univ., Pullman, WA (United States). Dept. of Biochemistry and Biophysics]; Hunter, L. [ed.] [National Insts. of Health, Bethesda, MD (United States). National Library of Medicine]; Klein, T.E. [ed.] [California Univ., San Francisco, CA (United States). Dept. of Pharmaceutical Chemistry]; PB: 508 p.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
CHIMERAS
STRUCTURE-ACTIVITY RELATIONSHIPS
PROTEINS
AMINO ACID SEQUENCE
DNA SEQUENCING
FUNCTIONAL MODELS
BIOSYNTHESIS
COMPUTER CODES
MATHEMATICAL MODELS
TRANSCRIPTION FACTORS
ABUNDANCE
BENCH-SCALE EXPERIMENTS
DESIGN
GENES
TRANSCRIPTION
GENE REGULATION
PROBABILITY