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Title: Interlaboratory collaborative study on sister chromatid exchange induction in vivo

Abstract

Nine laboratories participated in a comparative analysis of the ability of BP/PYR and 2AAF/4AAF to induce sister chromatid exchanges (SCEs) in vivo, using mice, rats and Chinese hamsters. Bone marrow, intestinal epithelium and peripheral blood lymphocytes were used as target tissues, following either gavage or intraperitoneal (ip) administration of the test chemical. Based on a statistical analysis of the SCE data by ANOVA and using an ..cap alpha.. of 0.05, BP induced a highly significant increase in SCEs in every tissue sampled in each species and among all strains of mice by both routes. Treatment with PYR induced a marginally positive SCE response in 5 of 15 experiments (considering male and female responses separately). By both routes, treatment with 2AAF induced a highly significant increase in SCE frequency in bone marrow cells of all mouse strains, in bone marrow and intestinal epithelial cells of Chinese hamsters. Treatment with 4AAF indiced a marginally positive SCE response in 6 of 15 experiments (considering male and female responses separately). The 2 carcinogens, BP and 2AAF, were clearly active regardless of species, strain, sex, tissue and route of administration and more potent than either of the two purportedly non-carcinogenic structural analogues, PYR and 4AAF,more » respectively. 40 refs., 10 figs., 19 tabs.« less

Authors:
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY (USA)
OSTI Identifier:
5488193
Report Number(s):
BNL-38070; CONF-8503244-1
ON: DE86011204
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Conference
Resource Relation:
Conference: Evaluation of short-term tests for carcinogens meeting, Cap D' Adge, France, 13 Mar 1985; Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACETYLAMINOFLUORENES; MUTAGENESIS; BENZOPYRENE; PYRENE; BONE MARROW CELLS; CRYPT CELLS; EXPERIMENTAL DATA; HAMSTERS; LYMPHOCYTES; MICE; RATS; SISTER CHROMATID EXCHANGES; ANIMAL CELLS; ANIMALS; AROMATICS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMOSOMAL ABERRATIONS; CONDENSED AROMATICS; CONNECTIVE TISSUE CELLS; DATA; HYDROCARBONS; INFORMATION; LEUKOCYTES; MAMMALS; MATERIALS; MUTATIONS; NUMERICAL DATA; ORGANIC COMPOUNDS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)

Citation Formats

Tice, R R. Interlaboratory collaborative study on sister chromatid exchange induction in vivo. United States: N. p., 1985. Web.
Tice, R R. Interlaboratory collaborative study on sister chromatid exchange induction in vivo. United States.
Tice, R R. 1985. "Interlaboratory collaborative study on sister chromatid exchange induction in vivo". United States.
@article{osti_5488193,
title = {Interlaboratory collaborative study on sister chromatid exchange induction in vivo},
author = {Tice, R R},
abstractNote = {Nine laboratories participated in a comparative analysis of the ability of BP/PYR and 2AAF/4AAF to induce sister chromatid exchanges (SCEs) in vivo, using mice, rats and Chinese hamsters. Bone marrow, intestinal epithelium and peripheral blood lymphocytes were used as target tissues, following either gavage or intraperitoneal (ip) administration of the test chemical. Based on a statistical analysis of the SCE data by ANOVA and using an ..cap alpha.. of 0.05, BP induced a highly significant increase in SCEs in every tissue sampled in each species and among all strains of mice by both routes. Treatment with PYR induced a marginally positive SCE response in 5 of 15 experiments (considering male and female responses separately). By both routes, treatment with 2AAF induced a highly significant increase in SCE frequency in bone marrow cells of all mouse strains, in bone marrow and intestinal epithelial cells of Chinese hamsters. Treatment with 4AAF indiced a marginally positive SCE response in 6 of 15 experiments (considering male and female responses separately). The 2 carcinogens, BP and 2AAF, were clearly active regardless of species, strain, sex, tissue and route of administration and more potent than either of the two purportedly non-carcinogenic structural analogues, PYR and 4AAF, respectively. 40 refs., 10 figs., 19 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/5488193}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}

Conference:
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