Expression of immediate early genes after treatment of human astrocytoma cells with radiation and taxol
- Columbia Univ., New York, NY (United States)
The promising chemotherapeutic agent, taxol, has been shown to sensitize the G18 line of human astrocytoma cells to ionizing radiation. The present studies were performed to identify specific changes in gene expression associated with this altered sensitivity. The products of immediate early genes, which are induced transiently in cells in response to a variety of treatments, including growth factors, neurotransmitters, and irradiation with UV light or X rays, are thought to initiate a cascade of genetic responses to alterations in cellular environment. The present results demonstrate a dramatic attenuation in one immediate early gene response in association with a treatment that enhances radiosensitivity in a refractory human brain tumor line. 22 refs., 5 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 54868
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 27, Issue 3; Other Information: PBD: 20 Oct 1993
- Country of Publication:
- United States
- Language:
- English
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