Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. [Dogs]
An in vivo measurement technique using /sup 15/O water and positron CT for quantitation of myocardial blood flow (MBF) was investigated. Oxygen-15 water radioactivity in myocardium was imaged with a NeuroECAT scanner for 10 min, starting at the time of tracer infusion. A separate scan following inhalation of /sup 15/O CO was obtained to label the blood pool and to help remove the contribution of radioactivity in the blood pool during the /sup 15/O water scans. The integrated projection technique was used for calculating MBF. The quantitative microsphere technique for measurement of MBF was performed along with the /sup 15/O water study to provide reference values, with which the MBF values by the in vivo technique were compared. Results of 12 experimental runs (in seven dogs) show the in vivo technique with /sup 15/O water and positron CT can give quantitative flow images of myocardium. The in vivo positron CT measurement was found to correlate well with the in vitro values (by microspheres) over the flow range of 40 to 150 ml/min/100 g.
- Research Organization:
- Univ. of California, Los Angeles
- DOE Contract Number:
- AC03-76SF01012
- OSTI ID:
- 5485281
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:6
- Country of Publication:
- United States
- Language:
- English
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BLOOD FLOW
DYNAMIC FUNCTION STUDIES
MYOCARDIUM
POSITRON COMPUTED TOMOGRAPHY
OXYGEN 15
DIAGNOSTIC USES
CARBON MONOXIDE
DOGS
EXPERIMENTAL DATA
MICROSPHERES
WATER
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DATA
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HYDROGEN COMPOUNDS
INFORMATION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics