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Title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Abstract

The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. Thus APOE-[epsilon]4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-[epsilon]4 was virtually sufficient to cause AD by age 80.

Authors:
; ; ; ; ;  [1];  [2];  [3];  [4]
  1. Duke Univ. Medical Center, Durham, NC (United States)
  2. Duke Univ. Medical Center, Durham, NC (United States) Durham VA Medical Center, CA (United States)
  3. Univ. of California, Los Angeles, CA (United States)
  4. Massachusetts General Hospital, Charlestown, MA (United States)
Publication Date:
OSTI Identifier:
5483040
Resource Type:
Journal Article
Journal Name:
Science (Washington, D.C.); (United States)
Additional Journal Information:
Journal Volume: 261:5123; Journal ID: ISSN 0036-8075
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; APOLIPOPROTEINS; GENES; NERVOUS SYSTEM DISEASES; RISK ASSESSMENT; HUMAN POPULATIONS; SCREENING; DISEASES; LIPIDS; LIPOPROTEINS; ORGANIC COMPOUNDS; POPULATIONS; PROTEINS; 550400* - Genetics

Citation Formats

Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, and Haines, J L. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. United States: N. p., 1993. Web. doi:10.1126/science.8346443.
Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, & Haines, J L. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. United States. https://doi.org/10.1126/science.8346443
Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, and Haines, J L. 1993. "Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families". United States. https://doi.org/10.1126/science.8346443.
@article{osti_5483040,
title = {Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families},
author = {Corder, E H and Saunders, A M and Strittmatter, W J and Gaskell, P C and Roses, A D and Petricak-Vance, M A and Schmechel, D E and Small, G W and Haines, J L},
abstractNote = {The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. Thus APOE-[epsilon]4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-[epsilon]4 was virtually sufficient to cause AD by age 80.},
doi = {10.1126/science.8346443},
url = {https://www.osti.gov/biblio/5483040}, journal = {Science (Washington, D.C.); (United States)},
issn = {0036-8075},
number = ,
volume = 261:5123,
place = {United States},
year = {Fri Aug 13 00:00:00 EDT 1993},
month = {Fri Aug 13 00:00:00 EDT 1993}
}