Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Abstract
The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. Thus APOE-[epsilon]4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-[epsilon]4 was virtually sufficient to cause AD by age 80.
- Authors:
-
- Duke Univ. Medical Center, Durham, NC (United States)
- Duke Univ. Medical Center, Durham, NC (United States) Durham VA Medical Center, CA (United States)
- Univ. of California, Los Angeles, CA (United States)
- Massachusetts General Hospital, Charlestown, MA (United States)
- Publication Date:
- OSTI Identifier:
- 5483040
- Resource Type:
- Journal Article
- Journal Name:
- Science (Washington, D.C.); (United States)
- Additional Journal Information:
- Journal Volume: 261:5123; Journal ID: ISSN 0036-8075
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; APOLIPOPROTEINS; GENES; NERVOUS SYSTEM DISEASES; RISK ASSESSMENT; HUMAN POPULATIONS; SCREENING; DISEASES; LIPIDS; LIPOPROTEINS; ORGANIC COMPOUNDS; POPULATIONS; PROTEINS; 550400* - Genetics
Citation Formats
Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, and Haines, J L. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. United States: N. p., 1993.
Web. doi:10.1126/science.8346443.
Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, & Haines, J L. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. United States. https://doi.org/10.1126/science.8346443
Corder, E H, Saunders, A M, Strittmatter, W J, Gaskell, P C, Roses, A D, Petricak-Vance, M A, Schmechel, D E, Small, G W, and Haines, J L. 1993.
"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families". United States. https://doi.org/10.1126/science.8346443.
@article{osti_5483040,
title = {Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families},
author = {Corder, E H and Saunders, A M and Strittmatter, W J and Gaskell, P C and Roses, A D and Petricak-Vance, M A and Schmechel, D E and Small, G W and Haines, J L},
abstractNote = {The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. Thus APOE-[epsilon]4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-[epsilon]4 was virtually sufficient to cause AD by age 80.},
doi = {10.1126/science.8346443},
url = {https://www.osti.gov/biblio/5483040},
journal = {Science (Washington, D.C.); (United States)},
issn = {0036-8075},
number = ,
volume = 261:5123,
place = {United States},
year = {Fri Aug 13 00:00:00 EDT 1993},
month = {Fri Aug 13 00:00:00 EDT 1993}
}
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