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Title: The biological effects of {sup 224}Ra injected into dogs

Abstract

The purpose of this study was to investigate the toxicity of injected {sup 224}Ra in the dog. Radium-224 is a short-lived isotope of radium with a half-life of 3.62 d. When administered parenterally, it deposits on bone surfaces; because of its short half-life, most of its energy is deposited on bone surfaces, in a manner similar to plutonium. The experimental design included a comparison to the exposed human population. Instead of using a single injection of {sup 224}Ra, groups were included in which dogs were injected once, 10 times, or 50 times. This design provided groups that could be compared to the multiple injections often used in people for the treatment of ankylosing spondylitis.

Authors:
;  [1]; ; ;
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  1. Univ. of Utah School of Medicine, Salt Lake City, UT (United States)
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
OSTI Identifier:
54811
Report Number(s):
ITRI-144
ON: DE95007526; TRN: 95:012752
DOE Contract Number:  
AC02-76EV00119; AC04-76EV01013
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Nov 1994; Related Information: Is Part Of Inhalation Toxicology Research Institute annual report, October 1, 1993--September 30, 1994; Belinsky, S.A.; Hoover, M.D.; Bradley, P.L. [eds.]; PB: 211 p.
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 05 NUCLEAR FUELS; SKELETON; NEOPLASMS; DEPOSITS; RADIUM 224; TOXICITY; INTRAVENOUS INJECTION; DOGS; BIOLOGICAL RADIATION EFFECTS; PROGRESS REPORT; HUMAN POPULATIONS; DOSIMETRY; ALPHA DECAY RADIOISOTOPES; COMPARATIVE EVALUATIONS; SPONDYLITIS; CHRONIC EXPOSURE; MAN

Citation Formats

Muggenburg, B A, Lloyd, R D, Hahn, F F, Griffith, W C, and Boecker, B B. The biological effects of {sup 224}Ra injected into dogs. United States: N. p., 1994. Web.
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Muggenburg, B A, Lloyd, R D, Hahn, F F, Griffith, W C, & Boecker, B B. The biological effects of {sup 224}Ra injected into dogs. United States.
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Muggenburg, B A, Lloyd, R D, Hahn, F F, Griffith, W C, and Boecker, B B. 1994. "The biological effects of {sup 224}Ra injected into dogs". United States.
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@article{osti_54811,
title = {The biological effects of {sup 224}Ra injected into dogs},
author = {Muggenburg, B A and Lloyd, R D and Hahn, F F and Griffith, W C and Boecker, B B},
abstractNote = {The purpose of this study was to investigate the toxicity of injected {sup 224}Ra in the dog. Radium-224 is a short-lived isotope of radium with a half-life of 3.62 d. When administered parenterally, it deposits on bone surfaces; because of its short half-life, most of its energy is deposited on bone surfaces, in a manner similar to plutonium. The experimental design included a comparison to the exposed human population. Instead of using a single injection of {sup 224}Ra, groups were included in which dogs were injected once, 10 times, or 50 times. This design provided groups that could be compared to the multiple injections often used in people for the treatment of ankylosing spondylitis.},
doi = {},
url = {https://www.osti.gov/biblio/54811}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 01 00:00:00 EST 1994},
month = {Tue Nov 01 00:00:00 EST 1994}
}
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Technical Report:
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