Effect of antiarrhythmic drugs on In-111-labeled leukocytes: chemotaxis and adherence to nylon wool
The influence of lidocaine (L) and procainamide (P) on the chemotactic ability and adherence to nylon wool of In-111-labeled human polymorphonuclear leukocytes (PMNs) was investigated. At the normal therapeutic levels of L (0.022 mM whole blood) or P (0.03 mM whole blood) no change in PMN function was observed. However, at and above five times the aforementioned blood levels of L, significant reduction in the chemotactic ability of PMNs was noted (p less than 0.005). The adverse effects of In-111 radiation appeared insignificant at all L or P concentrations during the 3-hr observation period. The labeled PMNs were resistant to the toxic effects of a higher concentration of P than that of L, and the reduction in PMN chemotaxis and adherence to nylon wool was not apparent until the P concentration reached 1.5 mM.
- Research Organization:
- Yale University School of Medicine, New Haven, Connecticut
- OSTI ID:
- 5478628
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, November 1, 1980-October 31, 1981
Nylon wool adherent accessory cell can augment CTL to MOPC 104E in the presence of 12-O-tetradecanoyl-phorbol-13-acetate (TPA)
Related Subjects
CARDIOVASCULAR AGENTS
BIOLOGICAL EFFECTS
LEUKOCYTES
ADHESION
INDIUM 111
MAN
SURFACE PROPERTIES
TRACER TECHNIQUES
WOOL
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIOISOTOPES
VERTEBRATES
550301* - Cytology- Tracer Techniques