Continuous infusion of tracer norepinephrine may miscalculate unidirectional nerve uptake of norepinephrine in humans

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Circulation Research; (USA)

DOI:https://doi.org/10.1161/01.RES.65.2.388· OSTI ID:5478070

Henriksen, J H; Christensen, N J; Ring-Larsen, H ^[1]

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1. Hvidovre Hospital (Denmark)

In order to evaluate uptake kinetics of norepinephrine (NE) in different tissues, a catheterization study was performed in control subjects (n = 6) and patients with enhanced sympathetic nervous activity (cirrhosis, n = 12) during constant intravenous infusion of L(3H)norepinephrine ((3H)NE) for 75 minutes. In spite of a higher NE spillover from kidneys in patients compared with controls (82 vs. 49 ng/min, p less than 0.01), renal extraction ratios of (3H)NE were similar in the two groups (0.33 vs. 0.32, NS), and no significant change was observed during the time of infusion. In contrast, liver-intestine extraction ratios of (3H)NE decreased significantly and equally with infusion time in patients (from 0.57 to 0.44, p less than 0.01) and controls (from 0.59 to 0.46, p less than 0.01). This was observed despite the fact that spillover of NE from this vascular bed was observed only in patients with cirrhosis and not in controls (41 vs. -5 ng/min, p less than 0.02). In the lower limb, net release of NE was similar in patients and controls, and extraction ratios of (3H)NE decreased almost equally with infusion time (from 0.35 to 0.30, p less than 0.01 and from 0.40 to 0.24, p less than 0.1, respectively). Whole-body clearance of (3H)NE decreased over time in patients (-6%, p less than 0.01) and controls (-20%, p less than 0.01), but significant difference was not observed between the groups. We conclude that failure to attain a steady state with respect to (3H)NE removal was demonstrated in areas of large tissue volume relative to blood flow.

• OSTI ID: 5478070
• Journal Information: Circulation Research; (USA), Vol. 65:2; ISSN 0009-7330
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NORADRENALINE
TISSUE DISTRIBUTION
AUTONOMIC NERVOUS SYSTEM
BLOOD FLOW
CLEARANCE
INTRAVENOUS INJECTION
LIVER CIRRHOSIS
MAN
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DRUGS
HYDROGEN COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
PRIMATES
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques