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Title: Chronic exposure to ozone causes restrictive lung disease

Abstract

A chronic study to determine the progression and/or reversibility of ozone-induced lung disease was conducted. Male rats were exposed to a diurnal pattern of ozone (O{sub 3}) for 1 week, 3 weeks, 3 months, 12 months, or 18 months. The occurrence of chronic lung disease was determined by structural and functional endpoints. Structurally, a biphasic response was observed with an initial acute inflammatory response after 1 week of exposure, a reduced acute response after 3 weeks of exposure, and an epithelial and interstitial response observed after 3 months which persisted or increased in intensity up to 18 months of exposure. Functional studies showed a persistence of decreased total lung capacity and residual volumes at 3, 12, and 18 months of exposure, a response indicative of restrictive lung disease. Biochemical changes in antioxidant metabolism were also observed after 12 and 18 months of exposure. Most significant changes were resolved after the clean-air recovery period. The study has shown that chronic exposure to O{sub 3} causes restrictive lung disease as characterized by the development of focal interstitial fibrosis.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
OSTI Identifier:
5477498
Report Number(s):
PB-89-224554/XAB; EPA-600/D-89/102
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 54 ENVIRONMENTAL SCIENCES; OZONE; BIOLOGICAL EFFECTS; RESPIRATORY SYSTEM DISEASES; ANATOMY; ANTIOXIDANTS; BIOCHEMISTRY; CHRONIC EXPOSURE; PHOSPHOLIPIDS; PHYSIOLOGY; RATS; ANIMALS; CHEMISTRY; DISEASES; ESTERS; LIPIDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RODENTS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 500200 - Environment, Atmospheric- Chemicals Monitoring & Transport- (-1989)

Citation Formats

Grose, E C, Costa, D L, Hatch, G E, Miller, F J, and Graham, J A. Chronic exposure to ozone causes restrictive lung disease. United States: N. p., 1989. Web.
Grose, E C, Costa, D L, Hatch, G E, Miller, F J, & Graham, J A. Chronic exposure to ozone causes restrictive lung disease. United States.
Grose, E C, Costa, D L, Hatch, G E, Miller, F J, and Graham, J A. 1989. "Chronic exposure to ozone causes restrictive lung disease". United States.
@article{osti_5477498,
title = {Chronic exposure to ozone causes restrictive lung disease},
author = {Grose, E C and Costa, D L and Hatch, G E and Miller, F J and Graham, J A},
abstractNote = {A chronic study to determine the progression and/or reversibility of ozone-induced lung disease was conducted. Male rats were exposed to a diurnal pattern of ozone (O{sub 3}) for 1 week, 3 weeks, 3 months, 12 months, or 18 months. The occurrence of chronic lung disease was determined by structural and functional endpoints. Structurally, a biphasic response was observed with an initial acute inflammatory response after 1 week of exposure, a reduced acute response after 3 weeks of exposure, and an epithelial and interstitial response observed after 3 months which persisted or increased in intensity up to 18 months of exposure. Functional studies showed a persistence of decreased total lung capacity and residual volumes at 3, 12, and 18 months of exposure, a response indicative of restrictive lung disease. Biochemical changes in antioxidant metabolism were also observed after 12 and 18 months of exposure. Most significant changes were resolved after the clean-air recovery period. The study has shown that chronic exposure to O{sub 3} causes restrictive lung disease as characterized by the development of focal interstitial fibrosis.},
doi = {},
url = {https://www.osti.gov/biblio/5477498}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}

Technical Report:
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