Comparative effects of chelating agents on distribution, excretion, and renal toxicity of inorganic mercury in rats

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Research Communications in Chemical Pathology and Pharmacology; (USA)

OSTI ID:5477203

Kojima, S; Shimada, H; Kiyozumi, M ^[1]

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1. Kumamoto Univ. (Japan)

The effects of three chelating agents, sodium N-benzyl-D-glucamine dithiocarbamate(NBG-DTC), 2,3-dimercaptopropanol(BAL), and D-penicillamine(D-PEN), on the distribution, excretion, and renal toxicity of inorganic mercury were compared in rats exposed to HgCl2. Rats were injected i.p. with 203HgCl2 (300 micrograms of Hg and 2 microCi of 203Hg/kg) and 30 min or 24 h later they were injected with a chelating agent (a quarter of an LD50). The injection of the chelating agents significantly enhanced the biliary and urinary excretions of mercury. BAL was the most effective for removal of mercury from the body at 30 min after mercury treatment. The extent of enhancing effect of the chelating agents for removal of mercury at 24 h after mercury was in the order NBG-DTC = BAL greater than D-PEN. The injection of BAL at 24 h after mercury treatment caused the redistribution of mercury to the heart and lung. NBG-DTC did not result in the redistribution of mercury to the heart, lung, and brain. Urinary excretion of protein and AST significantly increased 24-48 h after mercury treatment and decreased to the control values 72 h after mercury. The injection of the chelating agents at 30 min after mercury treatment significantly decreased the urinary excretion of protein and AST. In rats pretreated with mercury 24 h earlier, the chelating agents significantly decreased the urinary protein at 48 h after mercury treatment, but did not decrease the urinary AST. The results of this study indicate that the chelating agents are effective in removing mercury from the body, resulting in the protective effect against the mercury-induced renal damage.

• OSTI ID: 5477203
• Journal Information: Research Communications in Chemical Pathology and Pharmacology; (USA), Vol. 64:3; ISSN 0034-5164
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CHELATING AGENTS
BIOLOGICAL EFFECTS
MERCURY
TOXICITY
BILE
COMPARATIVE EVALUATIONS
GLUCOSE
MERCURY ISOTOPES
METABOLISM
PROTEINS
RATS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
DISTRIBUTION
ELEMENTS
HEXOSES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
RODENTS
SACCHARIDES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques