Assessment of skin ulcer healing capability by technetium-99m phosphate angiogram and blood-pool images
The accuracy of radionuclide angiography and blood-pool imaging using (/sup 99m/Tc)-phosphate to assess skin ulcer perfusion as an indicator of healing capacity was determined in 50 studies performed on 45 patients with nonhealing ulcers of the lower extremities. Two nuclear medicine physicians without clinical bias, graded the perfusion of the ulcer on the images as normal, increased or reduced with respect to the opposite limb. Patients were followed closely with aggressive local wound care for at least 14 days. Of the 31 ulcers which healed, the radionuclide study correctly predicted 30; of the 19 ulcers which did not heal, 14 were correctly predicted. Eight patients had osteomyelitis; four of those healed and four did not. The radionuclide study predicted healing in seven. This technique is a simple, reliable way to predict the microcirculatory adequacy for ulcer healing. Specificity is diminished in the presence of osteomyelitis.
- Research Organization:
- Univ. of Utah, Salt Lake City
- OSTI ID:
- 5476429
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD CIRCULATION
DYNAMIC FUNCTION STUDIES
LIMBS
SCINTISCANNING
OSTEOMYELITIS
HEALING
ULCERS
BIOMEDICAL RADIOGRAPHY
ISOMERIC NUCLEI
PATIENTS
SKIN
TECHNETIUM 99
TECHNETIUM PHOSPHATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BODY
BODY AREAS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RECOVERY
REFRACTORY METAL COMPOUNDS
SKELETAL DISEASES
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics