Cadmium accelerates bone loss in ovariectomized mice and fetal rat limb bones in culture

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.22.8761· OSTI ID:5473274

Bhattacharyya, M H; Whelton, B D; Stern, P H; Peterson, D P ^[1]

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1. Argonne National Lab., IL (USA)

Loss of bone mineral after ovariectomy was studied in mice exposed to dietary cadmium at 0.25, 5, or 50 ppm. Results show that dietary cadmium at 50 ppm increased bone mineral loss to a significantly greater extent in ovariectomized mice than in sham-operated controls. These results were obtained from two studies, one in which skeletal calcium content was determined 6 months after ovariectomy and a second in which {sup 45}Ca release from {sup 45}Ca-prelabeled bones was measured immediately after the start of dietary cadmium exposure. Furthermore, experiments with {sup 45}Ca-prelabeled fetal rat limb bones in culture demonstrated that Cd at 10 nM in the medium, a concentration estimated to be in the plasma of mice exposed to 50 ppm dietary Cd, strikingly increased bone resorption. These in vitro results indicate that cadmium may enhance bone mineral loss by a direct action on bone. Results of the in vivo studies are consistent with a significant role of cadmium in the etiology of Itai-Itai disease among postmenopausal women in Japan and may in part explain the increased risk of postmenopausal osteoporosis among women who smoke.

• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 5473274
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:22; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CADMIUM COMPOUNDS
BIOLOGICAL EFFECTS
CALCIUM 45
SECRETION
SKELETAL DISEASES
ETIOLOGY
BONE TISSUES
JAPAN
MICE
MINERALS
OSTEOPOROSIS
OVARIES
SKELETON
SURGERY
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
ASIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
FEMALE GENITALS
GONADS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
TISSUES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques