Phenotypic differences in survival to an experimental acute carbon monoxide intoxication
Male and female 45-day-old mice of two inbred (CBA and C57B1) and of one outbred (OF/sub 1/), SPF (specific pathogen free), strains, LD/sub 12/ /sub 12/ (L = 150 lx) synchronized, were submitted to an acute carbon monoxide challenge giving an overall survival close to 50%. Under these conditions significantly (P < 0.001) less CBA survived than the two other strains. A sex-related significant (P < 0.001) difference was observed in OF/sub 1/. Strain survival differences are independent of body weights and of respiratory and displacement activity, but appear to be related to behavior reactions towards environmental stresses. These phenotypic differences are similar to previous findings obtained with these three strains of mice submitted to a 50% survival acute hypoxic hypoxia (M. Stupfel, A. Perramon, P. Merat, J.M. Faure, and H. Masse, 1979, Comp. Biochem. Physiol., 64A, 317 to 323).
- Research Organization:
- French National Inst. of Health and Medical Research (INSERM), L'Arbresle, France
- OSTI ID:
- 5473082
- Journal Information:
- Environ. Res.; (United States), Vol. 21:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBON MONOXIDE
TOXICITY
MICE
BIOLOGICAL VARIABILITY
ACUTE EXPOSURE
BEHAVIOR
EXPERIMENTAL DATA
RESPIRATION
SEX DEPENDENCE
SURVIVAL CURVES
TABLES
ANIMALS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DATA
DATA FORMS
INFORMATION
MAMMALS
NUMERICAL DATA
OXIDES
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)