Splenic dynamics of indium-111 labeled platelets in idiopathic thrombocytopenic purpura

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5470699

Syrjaelae, M T.Sa.; Savolainen, S; Nieminen, U; Gripenberg, J; Liewendahl, K; Ikkala, E ^[1]

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1. Helsinki Univ. Central Hospital (Finland)

Splenic dynamics of {sup 111}In-labeled platelets and platelet-associated IgG in 33 patients with idiopathic thrombocytopenic purpura (ITP) were studied. Two half-lives were calculated for the biexponential splenic time-activity curve after i.v. injection of {sup 111}In-labeled platelets. There was no difference in the mean half-life of the rapid component of the splenic curve (ST1) when patients with negative or slightly positive platelet suspension immunofluorescence test (PSIFT) were compared to those with strongly positive PSIFT (3.0 {plus minus} 0.7 min vs. 3.6 {plus minus} 0.4, p greater than 0.05). Mean half-life of the slow component of the splenic curve (ST2) was found to be longer in patients with a strongly positive than a negative or weakly positive PSIFT (26 {plus minus} 5 min vs. 13.2 {plus minus} 1.0 min, p less than 0.01). It seems that determination of the two components of the splenic time-activity curve provides a useful method for studying platelet kinetics in ITP.

• OSTI ID: 5470699
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:9; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD PLATELETS
LABELLING
HEMIC DISEASES
DIAGNOSIS
SPLEEN
DYNAMIC FUNCTION STUDIES
BIOLOGICAL HALF-LIFE
FLUORESCENCE
IMMUNOGLOBULINS
INDIUM 111
PATIENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUMINESCENCE
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics